Three cases of gastrointestinal stromal tumors with metaiodobenzylguanidine (MIBG) accumulation

Honami Kobiyama; Shiro Ishii; Yumi Saito; Natsumi Kawamoto; Shigeyasu Sugawara; Hiroshi Ito

doi:10.5387/fms.24-00003

Case Report

Three cases of gastrointestinal stromal tumors with metaiodobenzylguanidine (MIBG) accumulation

Honami Kobiyama, Shiro Ishii, Yumi Saito, Natsumi Kawamoto, Shigeyasu Sugawara, Hiroshi Ito

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Keywords: gastrointestinal stromal tumor (GIST), metaiodobenzylguanidine (MIBG)

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2025 Volume 71 Issue 2 Pages 135-139

DOI http://doi.org/10.5387/fms.24-00003

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Abstract

Meta-iodobenzylguanidine (MIBG) is an analog of norepinephrine and guanethidine, and MIBG scintigraphy is useful to diagnose tumors of the sympathetic nervous system, such as pheochromocytoma, paraganglioma, and neuroblastoma.　To date, there have been few reports of MIBG accumulation in gastrointestinal stromal tumors (GISTs), so the mechanism and frequency of MIBG accumulation in GISTs are unknown.　Herein, we report and discuss three cases of GIST in which scintigraphy that was performed to exclude pheochromocytoma showed MIBG accumulation.

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